The McLean Hospital Translational Imaging Laboratory aims to provide cutting edge magnetic resonance imaging, functional imaging, chemical imaging (spectroscopy), and multimodal imaging services to the Harvard Catalyst Community. We have 3 magnetic resonance (MR) scanners, an ultra high magnetic field (9.4 Tesla) dedicated animal scanner and 3.0 and 4.0 Tesla large bore human systems available for large animal scans. Our scanners are capable of conducting scans in animals ranging in size from mice to large dogs, and we have experience imaging mice, rats, rabbits, nonhuman primates, and several canine species. All 3 scanners have dedicated animal prep areas. We offer high level biophysics, engineering, and data analytic expertise, along with veterinary technologist anesthesia support.
3.0 Tesla Siemens MRI Scanner
The 3T scanner also has:
* Preclinical prep area
9.4 Tesla Varian Direct Drive Scanner.
The 9.4T facility also includes:
* Rodent short-term holding area
* Rodent prep area
* Nonhuman primate short-term holding area
* Nonhuman primate prep area
Our high field human scanners support functional MRI studies in large animals that don't fit into our 29 cm animal scanner bore.
Our high field human scanners support phosphorus spectroscopy studies in large animals that don't fit into our 29 cm animal scanner bore.
Our high field human scanners support proton spectroscopy studies in large animals that don't fit into our 29 cm animal scanner bore.
Our high field human scanners support structural and diffusion MRI studies in large animals that don't fit into our 29 cm animal scanner bore.
Our high field human scanners are used for X-nuclear spectroscopy studies in animals that cannot fit into the 9.4T system 29 cm bore.
Our 9.4T system offers ultra high spatial resolution for phosphorus metabolites including ATP, PCr, Pi, phospholipids, and can noninvasively measure pH and magnesium concentration.
Our 9.4T system offers ultra high spatial, temporal, and spectral resolution for standard anatomical and diffusion imaging, and proton magnetic resonance spectroscopy. Our MRS program specializes in detection and quantification of proton metabolites relevant to brain disorders including GABA, glutamate, glutamine, glycine, and NAA, and can support brain temperature measurements.
Our 9.4T Facility is dedicated to animal research studies and is located in a building exclusively used for animal imaging research.
In addition to phosphorus spectroscopy, we support fluorine, lithium, carbon, and other X-nuclear spectroscopy.
Our 4T and 9.4T systems operate using the same software package, enabling us to conduct comparable imaging studies across platforms in multiple animal species, as well as in humans.
We support data analyses using a number of analytic tools including BrainVoyager, FSL, SPM, Freesurfer, ImageJ, LCModel, and others, and we develop customized scripts.
Our biophysicists and engineers have access to CAD software and a 3-D printer, enabling us to design and build customized animal handling equipment and transmit/receive coils.
We offer services to help develop new imaging protocols and customize existing ones.
Our trained veterinary technologist supports isoflurane, propofol, and ketamine anesthesia, and ancillary procedures (intravenous line placement, intubation).