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CHGR Chromosome Substitution Strain Resource (MGH)

Director: MacDonald, Marcy, Ph.D.

Location: Massachusetts General Hospital, Center for Human Genetic Research, Richard B. Simches Research Center, CPZN-5414, 185 Cambridge Street, Boston, MA 02114


This resource provides to MGH investigators a local source of breeding pairs of the 22 chromosome substitution strains (CSS)* of mice and access to basic phenotyping equipment for mapping of simple or complex traits, to promote the use of genetic mouse-based strategies in basic and clinical research.

The CSS Resource comprises 22 mouse lines, each homozygous for a single A/J chromosome (Chr 1-19, X or Y and mitochondria) on a genetic background that is otherwise C57BL/J that were generated by Dr. Joseph Nadeau (Case Western Reserve University) and his colleagues. The CSS mice are available from The Jackson Laboratories. However, to save time and money, the MGH CSS Resource maintains CSS breeding colonies that are housed in the Simches-8 barrier facility, adjacent to a procedure room that will have equipment for basic standardized phenotyping, including behavioral and metabolic measurements.





  • Breeding pair service ( Access service )

    Service provides: "breeding pairs of each of the 22 CSS lines as a local resource, already acclimatized to the MGH animal facility."

  • Dataset development ( Material processing service )

    Service includes: "the generation of genetic and phenotypic datasets that can be cross-compared to generate mouse trait maps."

  • Mouse Phenotyping Services ( Access service )

    Service provides: "access to basic mouse phenotyping equipment and standardized protocols."

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Last updated: 2019-05-17T13:43:25.369-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016