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DF/HCC Cancer Proteomics Center

Director: Libermann, Towia, Ph.D.

Location: Beth Israel Lahey Health/Beth Israel Deaconess Medical Center, Research North Building Room 380C, 99 Brookline Ave., Boston, MA 02115


The Core provides all of the tools of modern functional proteomics. Equipped with State-of-the-Art technologies for proteomics; protein profiling, protein identification, protein and peptide fractionation, and quantization. Personalized experimental design consultation, comprehensive individualized bioinformatics support.

The mission of the DF/HCC Cancer Proteomics Core is to develop a comprehensive and interdisciplinary proteomics core for High Sensitivity, High Resolution and High Throughput Proteomics with particular emphasis on in depth proteomic consultation, referral to the optimal proteomics facility and a strong focus on clinical sample analysis. The core will combine consultation, service and education into a comprehensive, translationally and clinically oriented proteomics core.






  • Bioinformatics analysis service ( Data analysis service )


    * Personalized consulting
    * Customized data analysis and interpretation
    * Web-based bioinformatics tools
    * Comprehensive and innovative Bioinformatics and visualization tools
    * Comprehensive annotation tools
    * Identification of Global Relationships
    * Incorporation of Biological Knowledge
    * Pathway Analysis
    * Publication ready figures
    * The Bioinformatics Core is also responsible for software support and development

  • Protein and peptide modifications identification service ( Material analysis service )


    * phosphorylation sites
    * protein modifications such as acetylation, methylation, and ubiqitination
    * By µLC/MS/MS
    * coomassie stain only, purified proteins

  • Protein identification by µLC/MS/MS ( Material analysis service )

    Includes coomassie and silver stained gel bands.

  • Protein profiling of complex biological samples ( Material analysis service )

    E.g. serum, urine, tissue, and cell extracts.


    *Profiling by µLC/MS
    *Multidimensional protein fractionation by µLC

  • Relative quantitation by µLC/MS/MS ( Material analysis service )


    * SILAC - stable isotope labeling of amino acids in cell culture which is a biosynthetic approach
    * GIST - global internal standard technology, a post digestion peptide level labeling technique.
    * ICAT - isotope coded affinity tag -based protein profiling
    * ITRAQ - isobaric peptide tagging system that enables you to label all primary amines, regardless of peptide class

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Last updated: 2020-04-23T15:28:05.446-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016