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Caspase-1-KO

eagle-i ID

http://harvard.eagle-i.net/i/0000013d-7df8-aabd-67e6-30e880000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/005346.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "Mice homozygous for the Il10 and Casp1 targeted mutations are viable and fertile when housed under SPF conditions. NOD/Lt mice deficient for both of these genes develop type 1 diabetes at a rate equivalent to the parental strains. The Il10 targeted mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions."
  3. Contact
    Lederer, James Ph.D.
  4. Related Disease
    colitis
  5. Related Disease
    cancer
  6. Related Disease
    anemia
  7. Related Disease
    hypersensitivity reaction type II disease
  8. Related Disease
    diabetes mellitus
  9. Parental Strain Name
    NOD (Non-Obese Diabetic)
  10. Biological process studied
    Inflammatory response
  11. Biological process studied
    Immune response
  12. Genetic Alteration(s)
    Caspase-1 null
  13. Developed by
    0000013f-a0b6-59de-1581-ccbb80000000
  14. Location
    Lederer Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016