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OTII TCR tg

eagle-i ID

http://harvard.eagle-i.net/i/0000013d-7de3-d652-67e6-30e880000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/004194.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction."
  3. Contact
    Lederer, James Ph.D.
  4. Parental Strain Name
    C57Bl/6
  5. Biological process studied
    T cell activation
  6. Genetic Alteration(s)
    T-Cell-Receptor-a-ova
  7. Genetic Alteration(s)
    T-Cell-Receptor-b-ova
  8. Developed by
    Butz, Eric
  9. Location
    Lederer Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016