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SKAT

eagle-i ID

http://harvard.eagle-i.net/i/0000013a-bc77-c1c2-0802-e06e80000000

Resource Type

  1. Algorithmic software component

Properties

  1. Resource Description
    "SKAT is a R package for performing (1) association tests between a set of common and rare SNPs and continuous and dichotomous (case-control) phenotypes using kernel machine methods for data from GWAS and genome-wide sequencing association studies (2) sample size and power calculatons for sequencing association studies."
  2. Used by
    Lin Laboratory
  3. Data Input
    SNP Data
  4. Data Output
    SNP-set level p-values, e.g. a gene or a region level p-value, while adjusting for covariates, such as principal components to account for population stratification
  5. Software purpose
    Statistical analysis and modeling objective
  6. Related Publication or Documentation
    Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.
  7. Related Publication or Documentation
    Optimal tests for rare variant effects in sequencing association studies
  8. Related Publication or Documentation
    Rare-variant association testing for sequencing data with the sequence kernel association test
  9. Website(s)
    http://www.hsph.harvard.edu/research/skat/index.html
  10. Developed by
    Lin, Xihong, Ph.D.
  11. Coded in
    SAS
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016