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Pharmacokinetics and Bioanalytical Chemistry

eagle-i ID

http://harvard.eagle-i.net/i/0000012c-f066-ba26-2162-17a280000000

Resource Type

  1. Core Laboratory

Properties

  1. Resource Description
    The Pharmacokinetics and Bioanalytical Chemistry Core (previously the DF/HCC Clinical Pharmacology Core) offers the expertise and laboratory capabilities required to undertake preclinical and clinical pharmacokinetic (PK) studies. Undertaking a PK study necessarily depends upon the ability to accurately and precisely measure the test drug in biological fluids and tissues. The physical facilities of the Core are a bioanalytical chemistry laboratory with dedicated instrumentation and technical staff. High performance liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) is well established as the technique of choice for the quantitative analysis of low molecular weight drugs in biological fluids. The Core has invested heavily in this methodology and presently has three LC-MS/MS systems. It also has HPLC systems with conventional detectors and a microtiter plate reader for ELISA and biochemical assays. The Core can readily establish and appropriately validate bioanalytical methods that have been developed in other laboratories as well as the de novo development of assays for newly discovered molecules. Every bioanalytical method established by the Core is appropriately validated and applied to the analysis of samples from PK studies as recommended by the current FDA Guidance for Industry. The Core is a fee for service facility that can be used by investigators at MGH and other MGB member institutions, the DF/HCC and other HMS institutions, external academic centers, and private pharmaceutical companies. A formal contractual agreement is not required for the Core to provide services to entities external to MGB or the DF/HCC.
  2. Contact
    Supko, Jeffrey, Ph.D.
  3. PI
    Supko, Jeffrey, Ph.D.
  4. Affiliation
    Dana-Farber/Harvard Cancer Center
  5. Affiliation
    Massachusetts General Hospital
  6. Website(s)
    http://www.dfhcc.harvard.edu/research/core-facilities/clinical-pharmacology/
  7. Director
    Supko, Jeffrey, Ph.D.
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    genoap (Genoa Polumbo)
  3. created
    2010-12-16T12:17:57.887-06:00
  4. creator
    etzameli (Effie Tzameli)
  5. modified
    2021-05-11T10:17:29.756-04:00

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