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NCDDG 1

eagle-i ID

http://harvard.eagle-i.net/i/0000012c-3c67-40ef-6d7a-cc8780000000

Resource Type

  1. Natural product extracts chemical library

Properties

  1. Library Source
    ICCB-Longwood Screening Facility (HMS)
  2. Resource Description
    384-well plate format. Concentration Information: Dried extracts resuspended at ~15 mg/ml in DMSO. This library was plated and added to the collection in September 2006. Production of this natural product extract library was funded by a National Cooperative Drug Discovery Group (NCDDG) grant from the NIH-NCI to the University of Utah, Harvard Medical School, and the University of British Columbia. The library contains partially purified extracts from endophytic fungi (fungi that live in higher plants) that grow in Costa Rica. The fungi have been collected and assembled by the National Biodiversity Institute (INBio) in Costa Rica. Crude extracts from each organism were obtained and further fractionated to eliminate nuisance compounds, especially those of high molecular weight or high polarity. This library was assembled under the Harvard Medical School portion of the NCDDG grant. Screening positives that have been confirmed by follow-up experiments on cherry picked samples can be further fractionated via a collaboration with the lab of Dr. Jon Clardy (Harvard Medical School). Please contact Caroline Shamu to arrange for purification of 'hit' compounds from extract samples.
  3. Contact
    Shamu, Caroline, Ph.D.
  4. Manufacturer
    National Biodiversity Institute of Costa Rica
  5. Access Restriction(s)
    Please note that ICCB-L provides these reagents only within the context of a full screen or an approved medicinal chemistry project.
  6. Website(s)
    https://iccb.med.harvard.edu/retired-libraries
  7. Library Count
    380 compounds
  8. Location
    ICCB-Longwood Screening Facility (HMS)
 
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