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NOD.Nk1.1

eagle-i ID

http://harvard.eagle-i.net/i/0000012a-25bf-7988-f5ed-943080000011

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Development: The surface marker NK1.1 is a receptor of the NKR-P1 family normally expressed in the C57BL/6 (B6) strain but not in the NOD strain. The NK1.1 cell surface receptor has been bred onto NOD mice, which carry a reported 10 cM of Chr. 6 from C57BL/6. A homozygous line was initiated from the progeny of the intercross. (Carnaud et al, Herbelin A, 2001). The line is currently at the >50th backcross to NOD/LtJ (2005). NK cells are B6-like and can be differentiated from NOD-like NK cells. NOD.NK1.1 mice express the NK1.1 marker selectively on the surface of their NK and NKT cell subsets. In addition, the mice may manifest slightly reduced disease incidence.
  2. Related Disease
    type 1 diabetes mellitus
  3. Related Publication or Documentation
    Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex.
  4. Parental Strain Name
    NOD
  5. Genetic Alteration(s)
    NK1.1 cell surface receptor insertion
  6. Clinical or Environmental Source
    Controlled facility at Jackson labs
  7. Phenotype Findings
    Improved NK cell performance compared with wild-type NOD mice
  8. Phenotype Findings
    Improved NK T cell performance compared with wild-type NOD mice
  9. Location
    Genetically Modified NOD Mouse Core Facility (HMS)
 
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016