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B6-H2g7

eagle-i ID

http://harvard.eagle-i.net/i/0000012a-25bf-7988-f5ed-94308000000a

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Development: B6.H2g7 is a congenic line developed by H Kikutani. This strain carries the NOD-derived MHC class II g7, haplotype, Iocated on Chromosome 17, but has all other genes from the B6 strain. The line is currently at the >20th generation. B6-H2g7 mice are viable, fertile, and present with no particular phenotype. They show no insulitis or diabetes (Luhder F et al, Mathis D, 2000). When crossed with BDC2.5 transgenic line, BDC2.5/B6g7 mice develop typical diabetes in most features, but, in contrast to the disease in BDC2.5/N or regular NOD animals, there is a quick transition from initial islet infiltration to massive destruction of the insulin-producing beta cells (Gonzalez A et al, Mathis D, 1997).
  2. Additional Name
    NOD-derived MHC class II g7, haplotype
  3. Related Disease
    type 1 diabetes mellitus
  4. Related Publication or Documentation
    Genetic control of diabetes progression.
  5. Parental Strain Name
    b6.H2g7
  6. Genetic Alteration(s)
    B6.H-2g7 insertion
  7. Clinical or Environmental Source
    Controlled Facility at Jackson labs
  8. Location
    Genetically Modified NOD Mouse Core Facility (HMS)
 
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016