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muMT[0]/N

eagle-i ID

http://harvard.eagle-i.net/i/0000012a-25bf-7988-f5ed-943080000002

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Development: The membrane exons of the gene encoding the mu-chain constant region were disrupted by insertion of a neomycin resistant gene (Kitamura et al., 1991). The mutation was then transferred from the original chimeric stock with a mixed 129/Sv and C57 BL/6 genome onto the NOD/Lt background (Serreze DV et al., 1996). The line is currently at the 14th backcross to NOD/LtJ (2005). Heterozygous mice are normal and fertile. NOD.uMTdeficient mice have normal numbers of T cells but are free of overt Diabetes and insulitis resistant. The frequency of disease in the B lymphocyte intact segregants is equivalent to that of standard NOD mice (Serreze DV et al., 1996). Homozygous uMT knock out animals display a high incidence of lymphoma of both T- and B-cell origin compared with these mutations on other genetic backgrounds.
  2. Related Disease
    non-Hodgkin lymphoma
  3. Related Disease
    B-cell lymphoma
  4. Related Disease
    type 1 diabetes mellitus
  5. Related Publication or Documentation
    B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.
  6. Related Publication or Documentation
    Susceptibility to lymphoid neoplasia in immunodeficient strains of nonobese diabetic mice.
  7. Related Publication or Documentation
    A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.
  8. Parental Strain Name
    129/Sv
  9. Parental Strain Name
    C57 BL/6
  10. Genetic Alteration(s)
    Immunoglobulin IgM deletion
  11. Clinical or Environmental Source
    Controlled facility at Jackson labs
  12. Phenotype Findings
    In homozygous animals however, B-cell development is stopped at the stage of pre-B-cell maturation and B cells are therefore absent.
  13. Phenotype Findings
    No IgM is present on the pre B cell surface.
  14. Phenotype Findings
    Greater incidence of autoimmune type 1 diabetes in NOD females than in males.
  15. Phenotype Findings
    The lymphoma incidence in is greater in females.
  16. Location
    Genetically Modified NOD Mouse Core Facility (HMS)
 
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