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Resource Type

  1. Mus musculus


  1. Resource Description
    Development: The membrane exons of the gene encoding the mu-chain constant region were disrupted by insertion of a neomycin resistant gene (Kitamura et al., 1991). The mutation was then transferred from the original chimeric stock with a mixed 129/Sv and C57 BL/6 genome onto the NOD/Lt background (Serreze DV et al., 1996). The line is currently at the 14th backcross to NOD/LtJ (2005). Heterozygous mice are normal and fertile. NOD.uMTdeficient mice have normal numbers of T cells but are free of overt Diabetes and insulitis resistant. The frequency of disease in the B lymphocyte intact segregants is equivalent to that of standard NOD mice (Serreze DV et al., 1996). Homozygous uMT knock out animals display a high incidence of lymphoma of both T- and B-cell origin compared with these mutations on other genetic backgrounds.
  2. Related Disease
    non-Hodgkin lymphoma
  3. Related Disease
    B-cell lymphoma
  4. Related Disease
    type 1 diabetes mellitus
  5. Related Publication or Documentation
    B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.
  6. Related Publication or Documentation
    Susceptibility to lymphoid neoplasia in immunodeficient strains of nonobese diabetic mice.
  7. Related Publication or Documentation
    A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.
  8. Parental Strain Name
  9. Parental Strain Name
    C57 BL/6
  10. Genetic Alteration(s)
    Immunoglobulin IgM deletion
  11. Clinical or Environmental Source
    Controlled facility at Jackson labs
  12. Phenotype Findings
    In homozygous animals however, B-cell development is stopped at the stage of pre-B-cell maturation and B cells are therefore absent.
  13. Phenotype Findings
    No IgM is present on the pre B cell surface.
  14. Phenotype Findings
    Greater incidence of autoimmune type 1 diabetes in NOD females than in males.
  15. Phenotype Findings
    The lymphoma incidence in is greater in females.
  16. Location
    Genetically Modified NOD Mouse Core Facility (HMS)
Provenance Metadata About This Resource Record

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