The Molecular Pathology Core Laboratory (MPCL) works to advance molecular pathology-based cancer research. The group addresses significant scientific and clinical research needs and has created a central hub where researchers can interact, collaborate, and utilize novel molecular pathology technologies to translate basic science discoveries into patient care applications for cancer. Our mission comprises comprehensive pathology annotation to encompass clinical, morphological, and molecular characteristics, genetic discovery in primary human tumors, with limited material and in real time, novel biomarker identification and pre-clinical trials, and transitioning assays to the clinical setting
"The ArcturusXT™ microdissection system offers a unique combination of infrared (IR) laser–enabled laser capture microdissection (LCM) and ultraviolet (UV) laser cutting in one platform. The ArcturusXT™ LCM instrument and reagents, combined with our downstream analysis platforms like those for Sanger sequencing, next-generation sequencing, and quantitative PCR, provide a complete solution for microgenomics research."
Paraffin tissue processing and embedding; frozen/FFPE tissue sectioning; H&E staining; cell pellet block preparation
Chromogenic IHC (single/dual); multiplex fluorescence IHC (up to 6 markers/slide).
LCM training and core operated services available, plus LCM instrument use.
Whole slide scanning – bright-field, fluorescence (10X, 20X, 40X); ROI image analysis – multispectral composite, segmentation, phenotyping, scoring TMA scanning and analysis.