The FAC represents a strategic interdisciplinary alliance between the Muscle Mechanics and Metabolomics Laboratory and the Laboratory of Exercise Physiology and Physical Performance at Brigham and Women’s Hospital, Harvard Medical School, and the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. The core provides standardized, state-of-the-art technologies to measure muscle performance, physical function, and disability in human and animal studies for OAIC’s pilot and exploratory projects and for several OAIC related projects funded through other sources.
The Laboratory of Exercise Physiology and Physical Function at BWH is a 1,000 square foot laboratory that includes private exam rooms, rest/changing room, and work stations for research staff. The Laboratory is staffed by two Master’s degree level Exercise Physiologists and a Research Assistant. A physician Medical Director provides general oversight. The laboratory has substantial experience in conducting and overseeing clinical trials in young adults as well as older persons with mobility limitations, fall history, and chronic diseases. The designated exercise space is equipped with state-of-the-art equipment are illustrated below.
This instrument measures the integrated EMG (iEMG) with wireless surface electrode probes for muscle contraction amplitude at varying loads. During total work tests, an analysis of the power spectrum allows quantification of fatigue and total work.
A dumbbell rack with dumbbells of assorted weights for strength and endurance measurements of smaller muscle groups, e.g., biceps, triceps, deltoids.
Keiser 300 pneumatic resistance leg extension and leg curl machines are stationed in the laboratory for added measurements of muscle strength and fatigability of the quadriceps and hamstring muscle groups.
Keiser 420 pneumatic resistance leg press and chest press machines with a computer interface that allows precise measurement and recording of muscle strength, power, fatigability, and contraction velocity. These instruments are used to accurately measure voluntary muscle strength, power, and fatigability.
Switch mats, photocells and electronic digital timers accurately measure speed during of physical function assessments such as stair climbing, gait speed and load carries.
This state-of-the-art, fully automated metabolic measurement system is integrated with a Mortara 12-lead electrocardiograph. The system is capable of assessing gas exchange breath-by-breath for measurement of aerobic capacity (〖"V" ̇"O" 〗_"2" "peak" ), the gas exchange lactate threshold, work efficiency, endurance, total work and the electrocardiogram.
ViaSprint electrically braked cycle ergometer with 1000 watt work rate capability. This cycle ergometer may be controlled by the Ultima Cardio2 computer in order to provide standardized ramp work rate protocols using small work rate increments (e.g., 0.08 to 1.7 watts per second).
Assess gas exchange breath-by-breath for measurement of aerobic capacity (〖"V" ̇"O" 〗_"2" "peak" ), the gas exchange lactate threshold, work efficiency, endurance, and total work.
Integrated EMG (iEMG) for amplitude of muscle contraction at varying loads and provides power spectrum analysis for measures of fatigue and total work.
Measure voluntary muscle strength, power, and fatigability.
Speed during physical function assessments such as stair climbing, gait speed and load carries.
Provide incremental work rate tests on cycle and/or treadmill.