The core offers Comprehensive Laboratory Animal Monitoring System (CLAMS) studies to noninvasively measure a variety of calorimetric and metabolic data in mice. The calorimetric data recorded by the system includes oxygen consumption and carbon dioxide production values, from which both heat values and respiratory exchange ratios (RER) can be calculated.
The Columbus Instruments Comprehensive Lab Animal Monitoring System (CLAMS) is a system of metabolic cages which allows for simultaneous measurement of numerous metabolic parameters including oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), food consumption, locomotor activity levels, and (using implantable transmitters) core body temperature and heart rate.
These instruments provide precise body composition measurements of fat, lean, free water, and total water masses in either tissue samples or live animals weighing up to 100 grams.
The BWH Metabolic Core FLIR T420SC Thermal Imaging Camera and ResearchIR software enable users to measure heat lost due to thermal radiation, a potentially significant mechanism of weight loss and energy homeostasis.
A Parr 6725EA Semimicro Calorimeter and 1107 Oxygen Bomb allow the BWH Metabolic Core to measure the energy content of fecal waste from mice following different genetic or environmental stimuli, enabling crucial assessment of food metabolism efficiency in experimental mice.