Research in my laboratory focuses on developmental oncobiology of epithelial cancer. We are particularly interested in understanding how cancer stem cells evolve from normal target cells of cancer through accumulation of mutations and through interaction with microenvironments, as avenues for identifying pathways unique to them. We study this mainly through developing and analyzing novel mouse models of human cancer based on genetic events occurring in patients. Currently, we focus on modeling recurrent chromosomal abnormalities recently identified in increasing numbers of epithelial cancers (e.g., breast cancer, prostate cancer). The in vivo studies are complemented by cell culture based studies to decipher molecular mechanisms underlying tumor initiation and progression.
Conditional knockin of NTRK3
Gata1 knock-in, exon 2 deleted
Igf1r conditional knock-out
Nkx3.1 null mouse
MMTV-Cre transgenic. Available from Jackson Labs.
Probasin-Androgen Receptor (E231G) transgenic. Available from Jackson Labs.