Daley Lab

Location: Children's Hospital Boston, Karp Family Research Laboratories, Room 7214, One Blackfan Circle, 300 Longwood Avenue, Boston, MA 02115

Summary:

Our laboratory is a multinational group located at Children's Hospital Boston. We study development, cellular reprogramming, disease processes, and the improvement of therapeutics with an emphasis on leukemia and genetic blood disorders. These projects build upon basic studies of pluripotent stem cells, the development of blood-forming or hematopoietic tissue, epigenetic regulation, and mechanisms of cancer initiation, progression, and therapy resistance.

Affiliations:

• Boston Children's Hospital

People:

• PI: Daley, George, M.D., Ph.D.
  

Resources:

Reagents

• CHB-1 ( Embryonic stem cell line )
  

  Cell Line: CHB-1
  NIH Registration Number: 0001* On Hold (see note below)
  NIH Approval Number: NIHhESC-09-0001
  
  * On Hold - NIH has received public comment on a proposed change to the definition of “human embryonic stem cells” in the NIH Guidelines for Human Stem Cell Research. While NIH is considering those public comments on the proposed change, this hESC line is currently on hold and should not be used in NIH-funded research. If grantees are currently using any of these lines they may contact the NIH Institute or Center that is funding their project for further information.

• CHB-10 ( Embryonic stem cell line )
  

  Cell Line: CHB-10
  NIH Registration Number: 0009
  NIH Approval Number: NIHhESC-09-0009

• CHB-11 ( Embryonic stem cell line )
  

  Cell Line: CHB-11
  NIH Registration Number: 0010
  NIH Approval Number: NIHhESC-09-0010

• CHB-12 ( Embryonic stem cell line )
  

  Cell Line: CHB-12
  NIH Registration Number: 0011
  NIH Approval Number: NIHhESC-09-0011

• CHB-2 ( Embryonic stem cell line )
  

  Cell Line: CHB-2
  NIH Registration Number: 0002
  * On Hold (see note below)
  NIH Approval Number: NIHhESC-09-0002
  
  * On Hold - NIH has received public comment on a proposed change to the definition of “human embryonic stem cells” in the NIH Guidelines for Human Stem Cell Research. While NIH is considering those public comments on the proposed change, this hESC line is currently on hold and should not be used in NIH-funded research. If grantees are currently using any of these lines they may contact the NIH Institute or Center that is funding their project for further information.

• CHB-3 ( Embryonic stem cell line )
  

  Cell Line: CHB-3
  NIH Registration Number: 0003
  * On Hold (see note below)
  NIH Approval Number: NIHhESC-09-0003
  
  * On Hold - NIH has received public comment on a proposed change to the definition of "human embryonic stem cells" in the NIH Guidelines for Human Stem Cell Research. While NIH is considering those public comments on the proposed change, this hESC line is currently on hold and should not be used in NIH-funded research. If grantees are currently using any of these lines they may contact the NIH Institute or Center that is funding their project for further information.

• CHB-4 ( Embryonic stem cell line )
  

  Cell Line: CHB-4
  NIH Registration Number: 0004
  NIH Approval Number: NIHhESC-09-0004

• CHB-5 ( Embryonic stem cell line )
  

  Cell Line: CHB-5
  NIH Registration Number: 0005
  NIH Approval Number: NIHhESC-09-0005

• CHB-6 ( Embryonic stem cell line )
  

  Cell Line: CHB-6
  NIH Registration Number: 0006
  NIH Approval Number: NIHhESC-09-0006

• CHB-8 ( Embryonic stem cell line )
  

  Cell Line: CHB-8
  NIH Registration Number: 0007
  NIH Approval Number: NIHhESC-09-0007

• CHB-9 ( Embryonic stem cell line )
  

  Cell Line: CHB-9
  NIH Registration Number: 0008
  NIH Approval Number: NIHhESC-09-0008

• GD-IPS1 ( Induced pluripotent stem cell line )
  

Web Links:

• http://daley.med.harvard.edu/