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Preclinical MRI Core Facility (BIDMC)

Director: Grant, Aaron, Ph.D.

Location: Beth Israel Deaconess Medical Center, Preclinical MRI Core Facility, 330 Brookline Avenue, Dana Building Rm 703, Boston MA 02215

Summary:

The Preclinical MRI Core Facility at the Beth Israel Deaconess Medical Center offers instrumentation and expertise for a broad range of magnetic resonance imaging and spectroscopy applications for small animals, excised tissue and cell culture studies. We provide fee for service within BIDMC and to outside investigators.

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Instruments

  • 4.7T Bruker Horizontal Bore MRI ( MRI Scanner )

    The actively shielded 40 cm bore system has the following two gradient sets available:

    - 26 cm ID (slew rates: 250 µsec, Maximum gradient: 9 G/cm)
    - 12 cm ID (slew rates: 120 µsec, Maximum gradient: 30 G/cm)

    In addition, there are a number of rf coils available for use, including:

    - bird cage coils 35 mm, 70 mm, 150 mm, 200 mm (ID)
    - surface coils, with active decoupling for receive-only operation 15 mm, 30 mm (ID)

  • 8.5T Bruker Vertical Bore MRI ( MRI Scanner )

    - The 8.5 Tesla vertical bore magnet is equipped with a self-shielded gradient set of 40 mm diameter ID and 75 G/cm maximum gradient strength.
    - A "micromouse" probe is available with a 30 mm ID proton rf coil which can be used for whole body mouse imaging. Cardiac and respiratory gating and monitoring are available with this probe, as are inhalation anesthetics.
    - A second probe is available with interchangeable rf coils, including:
    bird cage coils with internal diameters of 10 mm, 20 mm, 25 mm
    solenoid coils with diameters of 3 mm, 5 mm
    dual tuned coils of P31/H1 in 25 mm diameter
    surface coil of 1 cm diameter

  • 9.4T Bruker Horizontal Bore MRI ( MRI Scanner )

    Our newest 9.4T system is an actively shielded 20 cm bore system has the following two gradient sets available:

    - 120 mm ID maximum gradient amplitude 44 G/cm
    - 60 mm ID maximum gradient amplitude150 G/cm

    In addition, there are a number of rf coils available for use, including:

    - 84, 72,40 and 22 mm ID quadrature volume coils
    - Rat Heart Coil Array
    - Rat and Mouse Brain Array Surface Coils
    - 10mm and 20mm Planar Surface Coils
    - X-Nuclie 13C and 31P Surface Coils

  • Animal Anesthesia Equipment ( Anaesthetic vaporiser )

    "Facilities for inhalation anesthetics during imaging are available on all our MRI systems.

    A nose cone is used for anesthetic inhalation. Respiratory monitoring is available through the use of a pressure transducer placed on the abdominal area of the animal, and ECG monitoring is available through ECG leads. and can be used for triggering of the MRI sequences. Triggering can be respiratory, cardiac, or a combination."

  • Animal Monitoring & Gating System ( Animal physiology monitoring system )

    "The Model 1025L monitoring and gating system was designed to meet the physiological monitoring and gating needs for anesthetized mice, rats and larger animals in the PET, CT, SPECT, Optical and laboratory environments. The system consists of a main data acquisition and processing module located near the animal and a fiber optic transceiver (FORT) Module connected to a PC located near the operator console.

    The PC displays multiple waveforms, measured values, trends and gating pulses. The data Acquisition module is controlled by menu driven software from the PC.

    Options are available to measure the following parameters: ECG, respiration (two ways), temperature (two ways), pressure including invasive blood pressure, pulse oximetry and end-tidal CO2. "

Services

  • MR imaging and spectroscopy ( Material analysis service )

    Our facility provides non-invasive in vivo MR imaging and spectroscopy for a wide range of applications including but not limited to:
    - Anatomical Imaging
    - Monitoring Tumor Growth
    - Cardiac Function
    - Non-contrast Angiography
    - Biomechanics
    - Brain and Kidney Perfusion
    - Diffusion Imaging for Tissue Microstructure Analysis


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Last updated: 2014-04-16T13:33:23.500-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016