We are devoted to the study of theoretical population genetics. The goal of population genetics is to identify and to understand the forces that produce and maintain genetic variation in natural populations. These forces include mutation (also recombination and gene conversion), natural selection, various kinds of population structure (e.g. subdivision with migration), and the random fluctuations of gene frequencies through time known as genetic drift. We study these forces mathematically, using both analysis and computation. For more information about specific areas of research, follow the leads to lab members.
This program estimates the likelihood surface for these data using Monte Carlo integration (over genealogies).
Simulates the coalescent process in the large-number-of-demes metapopulation.
"Analytical calculation of joint site-frequency spectrum as in Wakeley and Hey (1997). Estimating ancestral population parameters."