Center for Biomedical OCT Research and Translation (MGH)

Director: Bouma, Brett, Ph.D.

Location: 40 Blossom Street, Bartlett Hall, RM 816, Boston, MA 02114

Summary:

The Center for Biomedical OCT Research and Translation (CBORT) is a National Biomedical Technology Resource Center (P41) funded by the National Institute of Biomedical Imaging and Bioengineering. Over the past two decades, Optical Coherence Tomography (OCT) has evolved into a powerful microscopy technique that can be used to safely image biological tissue. The mission of CBORT is to enable breakthroughs in biology and medicine through advancements in Optical Coherence Tomography (OCT) technology.

Affiliations:

• Massachusetts General Hospital

People:

• Director: Bouma, Brett, Ph.D.
  Email

Member: Namati, Jacqueline, Ph.D.
Role: Director of Program Development
Phone: (617) 724-5304
Email

Member: Vakoc, Ben, Ph.D.
Role: Associate Director
Email

Resources:

Instruments

• Brillouin microscopy systems ( Microscope )
  

• Commercial endoscopic OFDI system for use in animal or human studies ( Endoscopic workstation )
  

  Fully portable. ~7 μm resolution.

• Commercial intravascular OFDI system for use in animal studies ( Coherence tomography scanner )
  

  Fully portable. ~7 μm resolution.

• Custom built confocal fluorescence microscope ( Confocal microscope )
  

  3 fluorescence channels, various graded-index lens endoscopes for mouse imaging.

• Custom built two-photon microscope ( Two-photon confocal microscope )
  

  3 channels, second-harmonic generation capability.

• Intravascular ultrasound imaging system for use in animal studies ( Ultrasound machine )
  

  40 MHz frequency.

• OCT (OFDI) Imaging Systems ( Coherence tomography scanner )
  

  The center houses several custom built high-speed OCT systems (OFDI) for lab based imaging. ~7 μm resolution. Configured to work for imaging biological samples or small animals. Systems also include rotary junction for connection to catheters and endoscopes.

• Portable clinical OCT system optimized for skin imaging ( Coherence tomography scanner )
  

Research Opportunities

• Summer Workshops & Symposia ( Research Opportunity )
  

  CBORT hosts regular educational workshops and symposia intended to promote the field of OCT. Past summer workshops have included lectures as well as hands on laboratory elements for attendees to participate in. Topics include: source development, system integration, signal processing and system calibration, catheters and probes, and image processing and analysis. Please check back for upcoming announcements on future programs

Services

• OCT Consultation ( Support service )
  

  Potential and current users are encouraged to contact CBORT faculty to investigate potential opportunities for incorporating OCT into their research program. CBORT also provides assistance with protocol development and regulatory application processes.

• OCT Equipment Access ( Access service )
  

  Access to state of the art OCT and optical microscopy systems for pre-clinical and clinical research.

• OCT Imaging System Training ( Training service )
  

  Individual and Small Group Training: The individual and small group program is intended to provided customized training for an intensive few day visit or for a longer, 3-6 months, time period. During the visit trainees can decide to focus on advances in swept-source laser designs, development and fabrication of customizable OCT imaging probes and rotary junctions, as well as full OCT system integration and application based imaging techniques.
  
  The program has several focus areas including:
  • Laser Design
  • Imaging Probes & Rotary Junctions
  • OCT Systems Engineering
  • Clinical Imaging
  • Small Animal Imaging

Web Links:

• http://www.octresearch.org