The BWH Research Imaging Core (BRIC) provides a comprehensive research imaging service to meet the needs of investigators and research subjects using imaging facilities at Brigham and Women’s Hospital (BWH). The BRIC has been developed in close collaboration with the Brigham CTSA Imaging Team of the Harvard Catalyst Translational Imaging Program. A unique feature of BRIC is the complete anonymity of research subjects. Research image scheduling, image acquisition and image storage are all kept completely separate from BWH clinical Radiology systems. The BRIC provides the administrative infrastructure, customer service architecture and institutional support to promote investigative applications of imaging technologies.
Supports a broad spectrum of preclinical application fields, such as oncology, structural and functional neuroimaging, contrast agent development, stem cell research, ischemia, cardiology, and metabolic research.
"The In-Vivo Xtreme II provides comprehensive multimodal optical imaging that supports the broadest range of research objectives of any preclinical optical imaging system.
Five imaging modalities are provided, with co-registration of Bioluminescence Imaging (BLI), Multispectral VIS-NIR Fluorescence Imaging (MS-FLI), unique Direct Radioisotopic Imaging (DRI), Cherenkov Imaging (CLI), and X-ray Imaging."
The SkyScan 1176 is a high performance in vivo micro-CT scanner for preclinical research. The large format 11 megapixel x-ray camera combines resolution, image field size and scan speed. Image field width up to 68 mm allows full body mouse and rat scanning and distal limb scanning for big animals, such as rabbits, at pixel sizes of 9, 18 and 35µm. Variable x-ray energy and automatic filter changer provide scanning flexibility to allow imaging of a wide range of samples from lung tissue to bone with titanium implants.
Scanner integrates the power of 3.0T with a 70cm wide bore, and includes MultiDrive RF Transmit, Optical RF, a 50 cm usable FOV and high-performance gradients.
Lab contains two of these instruments.
"The new Super Argus PET/CT is the Argus PET/CT scanners evolution. The new scanner combine the "Unique Phoswich DOI Technology" from the Argus family with the highest FOV of the market (axial and transversal), which permits extending PET/CT studies to bigger animals."
Features include Diffusion Spectrum Imaging, TimTX TrueShape and syngo ZOOMit, depiction of smaller vessels without contrast agent with ToF angiography, enhanced flow effects with XR 80/200 gradient system and syngo DTI with up to 256 directions.
Lab contains two of these instruments.
Located in Bay 2.
Scanner is equipped with Tim (Total imaging matrix) technology, which provides up to 64 coil elements and up to 64 receive channels and DotGO.
With MAGNETOM Aera, the full applications coverage is standard and a comprehensive set of advanced applications is available. Features Tim 4G integrated with the consistency brought to your scanning by Dot.
Features include: 0.5 mm x 160 detector; 320; slices every rotation; 8 cm of coverage every rotation; 0.35 sec rotation; 72 kW generator; 78 cm bore; AIDR 3D Enhanced; PUREViSION CT Detector; SEMAR metal artifact reduction
The facility at 221 Longwood is equipped to do MRI imaging for both large and small animals.
Small animal (mouse and rat) imaging and housing is available at 221 Longwood in the BMRC facility in a BL2 housing facility run by the BWH CCM, and using a Bruker 7T small bore MRI magnet. Large animal imaging is also available on the Siemens 3T Skyra and GE 3T magnets in the BMRC facility. In the new BWH Building for Transformative Medicine (BTM), animal housing and imaging is available on 11th floor with the following 4 imaging devices: Bruker Biospec 3T Small Animal MRI, Bruker SkyScan 1176 mCT, Bruker In-Vivo Extreme II Optical/X-ray, Sedecal SuperArgus mPET/CT 4R.
Research assistants are available to perform MRI image segmentation, registration, tumor volume and dimension measurements, and time course analyses on preclinical images obtained through the BRIC.
"Image storage is provided through the research PACS system, including storage of research images from non-BWH institutions. There is a fee for importing and storing images from outside BWH."
"All subjects have a basic minimum set of images acquired in every imaging study. In all cases, a board certified/board eligible radiologist interprets this basic set of images. The radiology interpretation is limited to the basic set, not the research sequences that are acquired, and do not reveal subject identity and/or link to insurance information. The cost of the radiologist interpretation is included in BRIC scanning costs."
"MRI technologists are available during clinical scanning hours (and off-hours on L1 Bays 2 and 3) and their services are included in the scanning cost. fMRI scientists are available for an extra fee to conduct fMRI stimulation."
"A significant component of the BRIC’s infrastructure is information technology in the form of a Research PACS that mirrors the Clinical PACS in all functionalities and more and that separates the research subject’s data and information from scheduling to image acquisition and data management. Study subject screening and scheduling as well as image protocol and resultant data interpretation are provided in compliance with IRB protocols."