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Martinos Center for Biomedical Imaging Core Facility (MGH)

Director: Rosen, Bruce R., Ph.D., M.D.

Location: Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Suite 2301 Charlestown Navy Yard, Charlestown, MA 02129

Summary:

The Martinos Center's dual mission includes translational research and technology development. The core technologies being developed and used at the center are magnetic resonance imaging (MRI) and spectroscopy (MRS), magnetoencephalography (MEG) and electroencephalograpy (EEG), near infra-red spectroscopy (NIRS) and diffuse optical tomography (DOT), Positron Emission Tomography (PET), electrophysiology, molecular imaging, and computational image analysis. A particular area of innovation at the Center is Multimodal Functional Neuroimaging which involves the integration of imaging technologies. We are also world leaders in the development of primate neuroimaging techniques. Major areas of research at the center include, psychiatric, neurologic and neurovascular disorders, basic and cognitive neuroscience, cardiovascular disease, cancer and more. With an extensive and expanding inventory of state-of-the-art imaging facilities, a world class team of investigators and collaborators, and important government, industry and private supporters, the Martinos Center is leading the way to new advances and applications in biomedical imaging.

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Instruments

  • 3 Tesla Siemens Allegra 36 cm (gradient coil ID) head-only MRI ( 3T MRI scanner )

    "Capable of EPI, second order shimming, CINE, MR angiography, diffusion and perfusion studies, and spectroscopy. The asymmetric head gradient coil is capable of 60 mT/m and slew rates in excess of 600 T/m/s at a duty cycle of 70%, allowing single shot EPI with an echo spacing of 300 µs at a sustained rate of 14 images/second. Bay 3 also contains an assortment of audio, visual, and sensory stimuli equipment for fMRI studies including rear projection, audio stimulation, a subject response device and eyetracking setup."

  • 3T Siemens Trio 60 cm (RF coil ID) whole-body MRI ( 3T MRI scanner )

    "(Instrument has ) EPI, second order shimming, CINE, MR angiography, diffusion, perfusion, and spectroscopy capabilities for both neuro and body applications. This system uses the same gradients as the 1.5 T Sonata (40 mT/m strength, 200T/m/s slew rate). The system is equipped with 8 RF channel receivers accommodating up to 8 element array coils. An upgrade to perform multinuclear imaging and spectroscopy has recently been installed. Bay 4 also contains an assortment of audio, visual, and sensory stimuli equipment for fMRI studies including rear projection, audio stimulation, a subject response device and eyetracking setup."

  • Bruker Avance console with 4.7T Horizontal bore Magnex magnet ( NMR instrument )

    "This imager/spectrometer comprises an Oxford 4.7 T 33 cm horizontal bore magnet, a 20 G/cm gradient/shim system and a state of the art Bruker Instruments BioSpec/Avance dual RF channel multinuclear console. A 40 G/cm gradient coil insert is available. A wide variety of multinuclear imaging and spectroscopy experiments may be performed."

  • Bruker Avance spectrometer console with 14.1 T wide/vertical bore Magnex magnet ( NMR instrument )

    "A 14.1 T (600MHz) wide bore 8.9 cm actively screened vertical bore Magnex magnet and Bruker Avance spectrometer console has recently been installed. Capabilities include dual RF channels and deuterium lock; 5 mm and 10 mm direct and indirect observation high resolution (0.7 ppb) multinuclear multidimensional liquid state spectroscopy; high resolution (1.6 ppb) 1H and 13C MAS spectroscopy (including gradient spectroscopy); high power multinuclear cross polarization/magic angle spinning (CP/MAS) spectroscopy; an automated MAS sample changer; multinuclear microimaging and in vivo spectroscopy; actively screened gradients up to 100 g/cm; variable controlled temperature from -100°C to +150 °C with stability approaching 0.1°C."

  • Bruker Avance spectrometer console with 9.4T Horizontal bore Magnex magnet ( NMR instrument )

    "The 9.4T (400 Mhz proton frequency) 21cm dia. horizontal bore magnet (Magnex Scientific) utilizes a Bruker Advance console and is primarily for imaging and spectroscopy in small animals (rats and mice). Capabilities include high quality, high resolution anatomical and functional imaging, using a wide variety of contrast mechanisms(T1, T2, diffusion, perfusion), together with multi-shot 2D and 3D sequences, and single shot EPI. Multi-nuclear capabilities include high resolution localized spectroscopy and spectroscopic imaging. This imager/spectrometer is intended primarily for rodent studies, and consists of a 9.4 T 21 cm diameter horizontal bore Magnex magnet, Magnex gradient coil set capable of 20 G/cm, and a Bruker BioSpin (Karlsruhe, Germany and Billerica, MA) BioSpec/Avance dual RF channel multinuclear console."

  • Integrated 3D MR-PET imaging system ( Dual MRI-PET scanner )

    "The BrainPET is a 3D dedicated-brain scanner designed to operate inside the bore of the Siemens Medical MAGNETOM Trio, a TIM system 3T MR scanner (see Bay 8: 3T MR-PET laboratory, above) . The combined MR-PET scanner is the first system capable of simultaneously imaging the human brain in one bed position. The PET system consists of the following major components: PET gantry with 32 detector cassettes, gantry handling device with cable handling function, cooling system, acquisition electronics module, processing reconstruction station and power supply cabinet. The gantry physical ID and OD are 36 cm and 60 cm, respectively. The axial FOV is 19.25 cm and the transaxial FOV is ~30 cm. Each of the 32 PET detector modules consists of six 12×12 LSO crystal arrays read out by a 3×3 array of APDs (Hamamatsu 8664-55, Japan). The individual crystal size is 2.5×2.5×20 mm3. The APD signals are processed and shaped by an on-board charge-sensitive preamplifiers and pole-zero circuit."

  • Siemens MAGNETOM Avanto 1.5T MRI Scanner ( MRI Scanner )

    "It uses a 60 cm whole-body MRI capable of EPI functional imaging at a sustained rate of 15 images per second, CINE, MR angiography, diffusion and perfusion studies and spectroscopy. The system has a gradient strength of 45 mT/m and slew rate of 200 T/m/s, provides routine second order shimming and has 32 independent RF receive channels for phased array coils. Bay 2 also contains an assortment of audio, visual, and sensory stimuli equipment for fMRI studies including front and rear projection, audio stimulation, a subject response device and eye tracking setup. The stimulus equipment is setup to be run from either a PC, Macintosh or the users laptop computer. Stimuli can trigger or be triggered by the scanner. Bay 2 is also equipped with a Siemens Syngo workstation for 3D image processing, cardiac evaluation, and quantitative image analysis."

  • Ultrahigh field 7.0 T head-only MRI scanner ( MRI Scanner )

    "(This instrument has an) 80mT/m head gradient set and an Avano whole body gradient set. The 7.0 T 90 cm (magnet ID) whole-body magnet was built by Magnex Scientific (Oxford, UK), and the conventional MRI console, gradient drivers and patient table were provided by Siemens. Integration of these components and the design and construction of RF coils were performed by MGH and Siemens personnel. The 7T whole body magnet is augmented with a 80mT/m, 800 T/m/s slew rate head gradient set (Siemens) for echoplanar imaging and 2nd and 3rd order resistive shim coils under computer control. With its high performance gradient set, the system can provide better than 100-µm resolution. The system is shielded by a 460-ton steel shield."

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Last updated: 2015-11-19T14:40:05.903-06:00

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