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|  Harvard University |
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| Harvard University |
The X-ray diffraction facility in Harvard University offers single crystal X-ray data collection, structure solution and refinement of small molecule structures.
Equipped with Oxford Cyrosystream 700 series low temperature device. The laboratory provides routine small molecule (up to 500 non-hydrogen atoms) crystal structure determinations (80-400 K), including determinations of the absolute configuration of biologically active compounds, which often do not contain atoms with larger resonant scattering signals than that of oxygen.
APEX II CCD single crystal system (May, 2007) with a 3-axis goinometer and an Oxford Cryosystem 700 series low temperature device.
GZ6 Stereo microscope with a color camera for routine mounting of samples.
Used with Apex II CCD.
The instrument was purchased to support the research of Dr. Rachelle Gaudet and Dr. David Jeruzalmi. Permission for use or services are granted through these groups.
For routine mounting of samples.
"The X-Ray facility strongly encourages participation by the users in the structure determination, refinement and graphics interaction of molecular structure determinations. Users who wish to participate in single-crystal structure determination (DIY users) are free to do so if they have undergone the appropriate training."
The CSD is available to registered users of the laboratory and is accessed on the laboratory's PC and in the Department's Library. The Cambridge Structural Database contains bibliographic, 2D chemical and 3D structural results for organocarbon compounds studied by X-ray or neutron diffraction.
Charge density work includes: ultra-high resolution, low-temperature data collection; multipole refinement; and charge density analysis combined with theoretical calculations.
Comprehensive compilation of crystal structure data of inorganic compounds distributed by GMELIN-Institut and Fiz Karlsruhe.
"The laboratory uses the instrument provided by the Harvard Department of Molecular and Cellular Biology. This instrument includes a state-of-the-art R-AXIS area detector system. Permission for use or services are granted through Prof. Rachelle Gaudet."
The database is home to the single world wide repository for the processing and distribution of 3-D biological macromolecular structure data.
"Crystal quality is probably the single most important factor in determining the final precision for a given x-ray structural investigation. High precision structural result requires high-quality crystals. In general, crystals for an x-ray study must be single and of the proper size and shape. The crystal can usually be analyzed in-house if they are at least 0.05 mm thick in two dimensions. Micro-sized crystals that are difficult to get reasonable resolution data could be analyzed by using synchrotron radiation at the Advanced Photon Source."
